Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetic, and the New Therapeutics, Second Edition, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression and stromal-epithelial interaction has revealed many possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differntiation therapies, and gene therapy.
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